Baylor 's Brittney Griner (42) shoots Sunday as Louisville guard Shoni Schimmel (23) defends in their regional semifinal game in the women's NCAA tournament in Oklahoma City.

OKLAHOMA CITY - Shoni Schimmel scored 22 points and Monique Reid hit two free throws with 2.6 seconds left to lift sixth-seeded Louisville to a stunning 82-81 upset of top-ranked, defending national champion Baylor on Sunday night in the regional semifinals of the NCAA women's tournament.

Odyssey Sims scored 28 points and hit a pair of free throws with 9.1 seconds left to give the Lady Bears (34-2) their only lead of the game.

Reid caught an inbounds pass near the baseline after that and went coast to coast before getting fouled by All-American Brittney Griner on her way to the basket.

Sims had one last chance to save Baylor's season after Reid's free throws but was off-target and late on a desperation heave.

The Lady Bears had been practically invincible for the past four months, winning 32 straight games mostly by double digits.

Louisville (27-8) tied an NCAA record with 16 3-pointers to pull off the upset.

Norfolk Regional

• Notre Dame 93, Kansas 63

At Norfolk, Va., Skylar Diggins scored 22 of her 27 points by halftime Sunday and became the school's career scoring leader, helping the top-seeded Fighting Irish beat Kansas in the semifinals of the Norfolk Regional.

And Diggins made it look easy, adding nine assists and three steals, and scoring nine straight during a 16-2 first-half run that put the Irish (34-1) ahead to stay.

The victory was the 29th in a row for Notre Dame, and left the Irish one victory shy of a third consecutive trip to the Final Four. They have lost in the title game each of the last two years.

Carolyn Davis led the upstart Jayhawks (20-14) with 25 points on 11-for-17 shooting, but the second No. 12 seed ever to get this far in the women's tournament since the seeding format began in 1994 didn't stick around long.

• Duke 53, Nebraska 45

Tricia Liston scored 17 points and Duke shook off a slow start to beat Nebraska.

Alexis Jones added 14 points for the Blue Devils (33-2), who also struggled last weekend at home. They advanced to Tuesday night's game against top-seeded Notre Dame with a berth in the Final Four on the line.

The Cornhuskers (25-9), in the round of 16 for just the second time in school history, struggled from the field. They shot 30.3 percent and hit just 3 of 24 3-point tries. Nebraska entered the game averaging 6.4 3-pointers and made eight last week in stunning Texas A&M on its home floor.

Lindsey Moore led the Cornhuskers with 11 points, but on 5-of-18 shooting. Their leading scorer, Jordan Hooper, who averages 18.2 points, left with an apparent knee injury with eight minutes left and scored just six points.