Baylor 's Brittney Griner (42) shoots Sunday as Louisville guard Shoni Schimmel (23) defends in their regional semifinal game in the women's NCAA tournament in Oklahoma City.

OKLAHOMA CITY - Shoni Schimmel scored 22 points and Monique Reid hit two free throws with 2.6 seconds left to lift sixth-seeded Louisville to a stunning 82-81 upset of top-ranked, defending national champion Baylor on Sunday night in the regional semifinals of the NCAA women's tournament.

Odyssey Sims scored 28 points and hit a pair of free throws with 9.1 seconds left to give the Lady Bears (34-2) their only lead of the game.

Reid caught an inbounds pass near the baseline after that and went coast to coast before getting fouled by All-American Brittney Griner on her way to the basket.

Sims had one last chance to save Baylor's season after Reid's free throws but was off-target and late on a desperation heave.

The Lady Bears had been practically invincible for the past four months, winning 32 straight games mostly by double digits.

Louisville (27-8) tied an NCAA record with 16 3-pointers to pull off the upset.

The Cardinals will take on No. 2 seed Tennessee on Tuesday night for a trip to the women's Final Four.