Mckeena Rylie Copeland, 14, and Andruw Peyton, Jones, 16, may be traveling in a white 1997 Chevrolet Tahoe with Alabama tag number 28DG319, according to a news release.
Mckeena was last seen wearing a Kansas State ballcap and a blackheart necklace. She is 5 feet, 5 inches tall and weighs 145 lbs.
Jones is 6 feet tall and weighs 230 pounds. He was wearing blue jeans and a grey flannel shirt.
Anyone with information regarding their whereabouts is asked to call the sheriff's office at 256-845-380.