Christian Villanueva and Dustin Geiger hit two-run home runs for Tennessee, which clinched the series with the 4-0 win over Chattanooga on Sunday.
Andres Santiago pitched five scoreless innings for Chattanooga, allowing just two hits, but reliever Garrett Gould allowed Villanueva's homer to left-center in the sixth and Geiger's homer to right-center in the seventh.
The Lookouts dropped to 1-3 in the Southern League's second half and to 27-47 overall.
Game five of a five-game series at Tennessee is tonight at 7:15.
Raydel Sanchez (0-4, 7.11) is scheduled to start for the Lookouts, with Joe Gardner (1-0, 2.83) scheduled for the Smokies.