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Monday, November 9, 2026Nov 9

Oprah Winfrey erupts in HBO’s powerful ‘Henrietta Lacks’

This image released by HBO shows Rose Byrne, left, and Oprah Winfrey in a scene from HBO film "The Immortal Life of Henrietta Lacks,"  premiering Saturday at 8 p.m. EDT. (Quantrell Colbert/HBO via AP)
This image released by HBO shows Rose Byrne, left, and Oprah Winfrey in a scene from HBO film "The Immortal Life of Henrietta Lacks," premiering Saturday at 8 p.m. EDT. (Quantrell Colbert/HBO via AP) This image released by HBO shows Rose Byrne, left, and Oprah Winfrey in a scene from HBO film "The Immortal Life of Henrietta Lacks," premiering Saturday at 8 p.m. EDT. (Quantrell Colbert/HBO via AP)

NEW YORK (AP) – Oprah Winfrey doesn’t scare easy and she wasn’t frightened here.

“But I was unsure and uncertain of myself going into this role,” she says. “I did not want to do it. I never truly expected to do it. I had other people in mind to do it.”

Instead, it’s Winfrey who erupts in the new HBO film “The Immortal Life of Henrietta Lacks” as a tormented woman in search of the mother she never knew whose tissue sample would yield medical marvels benefiting millions.

The film, which premieres Saturday at 8 p.m. EDT, is based on the best-seller by Rebecca Skloot. It charts the rocky road to discovery shared by Henrietta Lacks’ daughter Deborah (Winfrey) with Skloot, who wanted to shine light on the human story behind the legendary cell line known as “HeLa.” Rose Byrne (“Damages,” ”Bridesmaids”) plays the intrepid reporter Skloot.

Winfrey was captivated by the book and acquired the rights with the intent of producing a film. Then two things happened to set the project on its proper course.