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Wednesday, November 11, 2026Nov 11

Titans shoot for sixth straight series win vs. Colts, who can’t seem to stop Derrick Henry

AP photo by Mark Zaleski / Tennessee Titans running back Derrick Henry leaves Indianapolis Colts safety Rodney Thomas II behind during an AFC South Division game on Oct. 23, 2022, in Nashville.
AP photo by Mark Zaleski / Tennessee Titans running back Derrick Henry leaves Indianapolis Colts safety Rodney Thomas II behind during an AFC South Division game on Oct. 23, 2022, in Nashville. AP photo by Mark Zaleski / Tennessee Titans running back Derrick Henry leaves Indianapolis Colts safety Rodney Thomas II behind during an AFC South Division game on Oct. 23, 2022, in Nashville.

INDIANAPOLIS — When the Indianapolis Colts watch video of prior matchups with Derrick Henry, they see a whole lot of failure.

They’ve spent seven years trying to slow down the powerful 6-foot-3, 247-pound, two-time NFL rushing champion, and nothing seems to work.

The Tennessee Titans star has run through them, around them, even stiff-armed them for seven 100-yard outings in 14 career games against Indianapolis. The first of two scheduled meetings this season between the AFC South Division rivals is Sunday — both teams enter 2-2 — and if the Colts want to snap their five-game losing streak to the Titans and coach Mike Vrabel, the defensive game plan is no secret.

“With Tennessee, you know Vrabel is going to have them ready to play, that they’re going to rally behind No. 22,” Colts linebacker Zaire Franklin said, referring to Henry’s jersey number.

Henry has 1,287 career rushing yards against Indianapolis, although the other two teams in the AFC South, the Houston Texans and Jacksonville Jaguars, have allowed even more yards to the 2015 Heisman Trophy winner, a second-round pick out of Alabama in the 2016 NFL draft.