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Thursday, October 29, 2026Oct 29

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Can a new nasal spray be used instead of an EpiPen?

Dr. Todd Levin
Dr. Todd Levin Dr. Todd Levin

Q: I heard there’s a new nasal spray that can be used instead of an EpiPen. Is that true?

A: Yes. The Food and Drug Administration recently approved Neffy, the first nasal spray form of epinephrine.

It’s used to treat severe allergic reactions, including anaphylaxis, in people weighing at least 33 pounds. Instead of a needle, you spray it into one nostril. If symptoms persist after five minutes, a second spray can be given.

This is an exciting option for people who carry an EpiPen or similar device. In emergencies, using a shot can feel intimidating, especially for children or adults who hesitate under stress. A nasal spray may be easier and less frightening to use.

Neffy works much like an auto-injector: It quickly raises blood pressure, reduces swelling, opens airways and stops the reaction from progressing. Clinical studies show results comparable to injectable epinephrine.